Amantadine hydrochloride
CAS No.: 665-66-7
Names: Amantadine Hydrochloride
MF: C10H15NH2.HCL Purity: 99%
Appearance: White Powder
Grade: Phamaceutical Grade
Assay: 99.0~101.0%
Shelf life: 2 years Package: 25kg/drum
introduction:
1) As Anti-virus medicine
Used to make intermediate of anti-virus medicine for treating A2 type flu virus, has antipyretic effect in the clinical pharmacology;
Amend fremitus and anaesthesia of Parkinson's disease symptom.
2) As pharmaceutical intermediate
Amantadine Hcl can be used as intermeditate to vildagliptin
3) As medicine to cure glaucoma
By blocking the NMDA receptor-mediated apoptosis, Amantadine Hcl has a great protective effect against RGC , then reduce and delay apoptosis of retinal tissue.
4) Raw material of catalyst
It can be as a raw material of catalyst to produce the new warm cataly, the applicant is very widely.
Amantadine Hydrochloride can pass through placenta and blood-brain barrier.
The half-life of normal renal function is 11~15 hours, and that of renal failure is 24 hours.
Long-term dialysis patients can reach 7~10 days. 2~4 h after oral administration, the peak blood concentration was about 0.3 g/ml.
The steady-state concentration was 0.2~0.9 g/ml within 2~3 days.
Mainly excreted by the kidneys. More than 90% of the patients were discharged with urine after glomerular filtration in their original shape, and some of them could be reabsorbed passively.
Excretion rate can be rapidly increased in acidic urine; A small amount is also excreted from milk.
Only a small percentage (about 4%) of patients on hemodialysis are cleared from blood.
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